Structural and functional aspects of Ebola virus proteins

S Jain, E Martynova, A Rizvanov, S Khaiboullina… - Pathogens, 2021 - mdpi.com
Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented,
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …

The Ebola virus soluble glycoprotein contributes to viral pathogenesis by activating the MAP kinase signaling pathway

W Furuyama, K Shifflett, H Feldmann, A Marzi - PLoS pathogens, 2021 - journals.plos.org
Ebola virus (EBOV) expresses three different glycoproteins (GPs) from its GP gene. The
primary product, soluble GP (sGP), is secreted in abundance during infection. EBOV sGP …

The roles of Ebola virus soluble glycoprotein in replication, pathogenesis, and countermeasure development

W Zhu, L Banadyga, K Emeterio, G Wong, X Qiu - Viruses, 2019 - mdpi.com
Ebola virus (EBOV) is a highly lethal pathogen that has caused several outbreaks of severe
hemorrhagic fever in humans since its emergence in 1976. The EBOV glycoprotein (GP1, 2) …

[HTML][HTML] The lifecycle of the Ebola virus in host cells

DS Yu, TH Weng, XX Wu, FXC Wang, XY Lu, HB Wu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Ebola haemorrhagic fever causes deadly disease in humans and non-human primates
resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However …

A new Ebola virus nonstructural glycoprotein expressed through RNA editing

M Mehedi, D Falzarano, J Seebach, X Hu… - Journal of …, 2011 - Am Soc Microbiol
Ebola virus (EBOV), an enveloped, single-stranded, negative-sense RNA virus, causes
severe hemorrhagic fever in humans and nonhuman primates. The EBOV glycoprotein (GP) …

The Ebola Virus Glycoprotein Contributes to but Is Not Sufficient for Virulence In Vivo

A Groseth, A Marzi, T Hoenen, A Herwig, D Gardner… - 2012 - journals.plos.org
Among the Ebola viruses most species cause severe hemorrhagic fever in humans;
however, Reston ebolavirus (REBOV) has not been associated with human disease despite …

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it

JE Lee, EO Saphire - Current opinion in structural biology, 2009 - Elsevier
The ebolavirus (EBOV) envelope glycoprotein (GP) is solely responsible for viral attachment
to, fusion with, and entry of new host cells, and consequently is a major target of vaccine …

Endoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function

RJ Wool-Lewis, P Bates - Journal of virology, 1999 - Am Soc Microbiol
Proteolytic processing is required for the activation of numerous viral glycoproteins. Here we
show that the envelope glycoprotein from the Zaire strain of Ebola virus (Ebo-GP) is …

The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein

PJ Dziubańska, U Derewenda, JF Ellena… - … Section D: Biological …, 2014 - journals.iucr.org
Ebolavirus (EBOV) causes severe hemorrhagic fever with a mortality rate of up to 90%.
EBOV is a member of the order Mononegavirales and, like other viruses in this taxonomic …

Disulfide bond assignment of the Ebola virus secreted glycoprotein SGP

LG Barrientos, AM Martin, PE Rollin… - … and biophysical research …, 2004 - Elsevier
The non-structural glycoprotein (SGP) of Ebola virus (EboV) is secreted in large amounts
from infected cells as a disulfide-linked homodimer. In this communication, highly purified …