Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the
extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and …

The function of the integrin family of receptors as central mediators of cell-extracellular
matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and …

Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As
the major force-bearing adhesion-receptor protein, integrins have a central role in how cells …

Forces acting on cells govern many important regulatory events during development, normal
physiology, and disease processes. Integrin-mediated adhesions, which transmit forces …

While it is self-evident that all extracellular molecules are an integral part of a multicellular
organism, it is paradoxical that they are often considered to be dissociated from cells. The …

Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now
well established that signaling by integrins mediates many of these effects. Ten years of …

Cells sense cues that guide their growth and development by probing their
microenvironment with surface membrane receptors that elicit intracellular signals when …

Cells sense and respond to the biochemical and physical properties of the extracellular
matrix (ECM) through adhesive structures that bridge the cell cytoskeleton and the …

Cell-matrix adhesion complexes are multi-protein structures linking the extracellular matrix
(ECM) to the cytoskeleton. They are essential to both cell motility and function by …