Factors controlling permeability of the blood–brain barrier

MMA Almutairi, C Gong, YG Xu, Y Chang… - Cellular and molecular life …, 2016 - Springer
As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

[HTML][HTML] Factors influencing the blood-brain barrier permeability

Y Zhao, L Gan, L Ren, Y Lin, C Ma, X Lin - Brain research, 2022 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

The molecular constituents of the blood–brain barrier

BW Chow, C Gu - Trends in neurosciences, 2015 - cell.com
The blood–brain barrier (BBB) maintains the optimal microenvironment in the central
nervous system (CNS) for proper brain function. The BBB comprises specialized CNS …

The “frail” brain blood barrier in neurodegenerative diseases: Role of early disruption of endothelial cell-to-cell connections

J Maiuolo, M Gliozzi, V Musolino, M Scicchitano… - International journal of …, 2018 - mdpi.com
The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular
component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and …

Blood–brain barrier: structural components and function under physiologic and pathologic conditions

Y Persidsky, SH Ramirez, J Haorah… - Journal of Neuroimmune …, 2006 - Springer
The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …

Looking at the blood–brain barrier: molecular anatomy and possible investigation approaches

FL Cardoso, D Brites, MA Brito - Brain research reviews, 2010 - Elsevier
The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

C Yang, KE Hawkins, S Doré… - American Journal of …, 2019 - journals.physiology.org
As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

[HTML][HTML] Formation and maintenance of the BBB

M Blanchette, R Daneman - Mechanisms of development, 2015 - Elsevier
The central nervous system (CNS) is vascularized by a dense capillary network that is
critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from …

Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …

F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

Junctional complexes of the blood–brain barrier: permeability changes in neuroinflammation

MA Petty, EH Lo - Progress in neurobiology, 2002 - Elsevier
A wide range of central nervous system (CNS) disorders include neuroinflammatory events
that perturb blood–brain barrier (BBB) integrity. Mechanisms by which the BBB responds to …