Heterocyclic compounds as a magic bullet for diabetes mellitus: a review
Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …
increasing all over the world. From the last two decades, the use of synthetic agents has …
Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2, 4-dione analogues as new class of anti-hyperglycemic agents
In this work, three isoxazoline-thiazolidine-2, 4-dione derivatives were synthesized and
characterized by FT-IR, 1H-NMR, 13C-NMR and ESI-MS spectrometry. All compounds have …
characterized by FT-IR, 1H-NMR, 13C-NMR and ESI-MS spectrometry. All compounds have …
Thiazolidinedione derivatives: in silico, in vitro, in vivo, antioxidant and anti-diabetic evaluation
MY Sameeh, MM Khowdiary, HS Nassar, MM Abdelall… - Molecules, 2022 - mdpi.com
This work aimed to synthesize a new antihyperglycemic thiazolidinedione based on the
spectral data. The DFT\B3LYP\6-311G** level of theory was used to investigate the frontier …
spectral data. The DFT\B3LYP\6-311G** level of theory was used to investigate the frontier …
Synthesis, in-Silico studies and biological evaluation of pyrimidine based thiazolidinedione derivatives as potential anti-diabetic agent
Despite the advancements in the management of Diabetes mellitus, the design and
synthesis of drug molecule which ameliorates the hyperglycemia and associated secondary …
synthesis of drug molecule which ameliorates the hyperglycemia and associated secondary …
Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives
Currently, available therapies for diabetes could not achieve normal sugar values in a high
percentage of treated patients. In this research project, a series of 17 benzodioxole …
percentage of treated patients. In this research project, a series of 17 benzodioxole …
Experimental and Computational Analysis of Newly Synthesized Benzotriazinone Sulfonamides as Alpha-Glucosidase Inhibitors
Diabetes mellitus is a chronic metabolic disorder in which the pancreas secretes insulin but
the body cells do not recognize it. As a result, carbohydrate metabolism causes …
the body cells do not recognize it. As a result, carbohydrate metabolism causes …
Discovery potent of thiazolidinedione derivatives as antioxidant, α-amylase inhibitor, and antidiabetic agent
MY Sameeh, MM Khowdiary, HS Nassar, MM Abdelall… - Biomedicines, 2021 - mdpi.com
This work aimed to synthesize safe antihyperglycemic derivatives bearing thiazolidinedione
fragment based on spectral data. The DFT theory discussed the frontier molecular orbitals …
fragment based on spectral data. The DFT theory discussed the frontier molecular orbitals …
Alpha-glucosidase activity of novel pyrazolobenzothiazine 5, 5-dioxide derivatives for the treatment of diabetes mellitus. Invitro combined with molecular docking …
Diabetes mellitus is a metabolic disease caused due to the improper secretion of insulin
which leads to hyperglycaemia. According to the International Diabetes Federation (IDF) …
which leads to hyperglycaemia. According to the International Diabetes Federation (IDF) …
Synthesis, docking and ADMET studies of novel chalcone triazoles for anti-cancer and anti-diabetic activity
A series of novel chalcone-triazole derivatives were synthesized and screened for in vitro
anticancer activity on the human cancer cell lines IMR32 (neuroblastoma), HepG2 …
anticancer activity on the human cancer cell lines IMR32 (neuroblastoma), HepG2 …