NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

[HTML][HTML] Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

[HTML][HTML] Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches

MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …

NF‐κB as a potential molecular target for cancer therapy

CH Lee, YT Jeon, SH Kim, YS Song - Biofactors, 2007 - Wiley Online Library
Nuclear factor κB (NF‐κB), a transcription factor, plays an important role in carcinogenesis
as well as in the regulation of immune and inflammatory responses. NF‐κB induces the …

[HTML][HTML] NF-kappaB: two sides of the same coin

BRB Pires, RCMC Silva, GM Ferreira, E Abdelhay - Genes, 2018 - mdpi.com
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

NF-κB, an active player in human cancers

Y Xia, S Shen, IM Verma - Cancer immunology research, 2014 - AACR
NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

Deregulation of NF-κB and its upstream kinases in cancer

SC Sun, G Xiao - Cancer and Metastasis Reviews, 2003 - Springer
The transcription factor NF-κB is known for its function in regulating immune and
inflammatory responses. However, recent evidence suggests that NF-κB also plays a pivotal …

NF-κB signaling pathway and its therapeutic implications in human diseases

FH Sarkar, Y Li, Z Wang, D Kong - International reviews of …, 2008 - Taylor & Francis
The nuclear factor-κB (NF-κB) pathway is one of the most important cellular signal
transduction pathways involved in both physiologic processes and disease conditions. It …

[HTML][HTML] Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

NF-κB as a therapeutic target in chronic inflammation: recent advances

SS Makarov - Molecular medicine today, 2000 - cell.com
The family of nuclear factor κB (NF-κB) transcription factors is a topic of intense interest in the
biomedical community stemming from the role NF-κB plays in almost every aspect of cell …