[HTML][HTML] And then there was light: perspectives of optogenetics for deep brain stimulation and neuromodulation

J Delbeke, L Hoffman, K Mols, D Braeken… - Frontiers in …, 2017 - frontiersin.org
Deep Brain Stimulation (DBS) has evolved into a well-accepted add-on treatment for
patients with severe Parkinsons disease as well as for other chronic neurological conditions …

From optogenetic technologies to neuromodulation therapies

JC Williams, T Denison - Science translational medicine, 2013 - science.org
The field of optogenetics has provided new insight into neuronal communication and
complex brain function. Now, scientists eagerly anticipate clinical application of this …

[PDF][PDF] Optogenetically inspired deep brain stimulation: linking basic with clinical research

C Lüscher, P Pollak - Swiss Medical Weekly, 2016 - smw.ch
In the last decade, optogenetics has revolutionised the neurosciences. The technique, which
allows for cell-type specific excitation and inhibition of neurons in the brain of freely moving …

Translating insights from optogenetics into therapies for Parkinson's disease

AH Gittis, EA Yttri - Current opinion in biomedical engineering, 2018 - Elsevier
Movement disorders including Parkinson's disease and dystonia are caused by neurological
dysfunction, typically resulting from the loss of a neuronal input within a circuit …

Optogenetic cell control in experimental models of neurological disorders

J Tønnesen - Behavioural brain research, 2013 - Elsevier
The complexity of the brain, in which different neuronal cell types are interspersed and
complexly interconnected, has posed a major obstacle in identifying pathophysiological …

Taking optogenetics into the human brain: opportunities and challenges in clinical trial design

M White, M Mackay, RG Whittaker - Open access journal of clinical …, 2020 - Taylor & Francis
Optogenetics, the use of light to control the activity of suitably sensitized cells, has led to
major advances in the field of basic neuroscience since it first emerged in 2005. Already, the …

Optogenetic neuromodulation

PSA Kalanithi, JM Henderson - International review of neurobiology, 2012 - Elsevier
The recent development of optogenetics, a revolutionary research tool in neuroscience,
portends an evolution of current clinical neuromodulation tools. A form of gene therapy …

New era of optogenetics: from the central to peripheral nervous system

X Xu, T Mee, X Jia - Critical reviews in biochemistry and molecular …, 2020 - Taylor & Francis
Optogenetics has recently gained recognition as a biological technique to control the activity
of cells using light stimulation. Many studies have applied optogenetics to cell lines in the …

[HTML][HTML] Optogenetics for controlling seizure circuits for translational approaches

M Ledri, M Andersson, J Wickham, M Kokaia - Neurobiology of Disease, 2023 - Elsevier
The advent of optogenetic tools has had a profound impact on modern neuroscience
research, revolutionizing our understanding of the brain. These tools offer a remarkable …

Optogenetic neuromodulation

JM Henderson, T Federici, N Boulis - Neurosurgery, 2009 - journals.lww.com
Abstract MODULATION OF THE nervous system by electrical or chemical means
(neuromodulation) is becoming increasingly sophisticated, with application to a growing …