Effect modification between genes and environment and Parkinson's disease risk

MT Periñán, K Brolin, S Bandres‐Ciga… - Annals of …, 2022 - Wiley Online Library
Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and
environmental factors interact to contribute to its etiology. Remarkable progress has been …

Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease

M Tsalenchuk, SM Gentleman, SJ Marzi - npj Parkinson's Disease, 2023 - nature.com
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

Gene–environment interactions: key to unraveling the mystery of Parkinson's disease

HM Gao, JS Hong - Progress in neurobiology, 2011 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
gradual, irreversible loss of dopamine neurons in the substantia nigra is the signature lesion …

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

JR Cannon, JT Greenamyre - Neurobiology of disease, 2013 - Elsevier
Interactions between genetic factors and environmental exposures are thought to be major
contributors to the etiology of Parkinson's disease. While such interactions are poorly …

Genetic profile, environmental exposure, and their interaction in Parkinson's disease

L Polito, A Greco, D Seripa - Parkinson's disease, 2016 - Wiley Online Library
The discovery of causative mutations for Parkinson's disease (PD) as well as their functional
characterization in cellular and animal models has provided crucial insight into the …

Gene–environment interactions in Parkinson's disease

CA Ross, WW Smith - Parkinsonism & related disorders, 2007 - Elsevier
PD is the second most common neurodegenerative disease, and affects 5% of the
population by the age of 85. PD is a multi-factorial disease with a complex etiology including …

Environmental impact on the epigenetic mechanisms underlying Parkinson's disease pathogenesis: a narrative review

E Angelopoulou, YN Paudel, SG Papageorgiou… - Brain Sciences, 2022 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder with an
unclear etiology and no disease-modifying treatment to date. PD is considered a …

Gene–Environment Interactions for Parkinson's Disease

A Reynoso, R Torricelli, BM Jacobs, J Shi… - Annals of …, 2024 - Wiley Online Library
Objective Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology.
Multiple genetic and environmental factors have been associated with PD, but most PD risk …

Gene–environment interactions in Parkinson's disease: the importance of animal modeling

MP Horowitz, JT Greenamyre - Clinical Pharmacology & …, 2010 - Wiley Online Library
Parkinson's disease (PD), a late‐onset neurodegenerative disorder, occurs most commonly
in a “sporadic”(idiopathic) form, without a clearly defined genetic basis and only a vaguely …

[HTML][HTML] Parkinson's disease and the environment

N Ball, WP Teo, S Chandra, J Chapman - Frontiers in neurology, 2019 - frontiersin.org
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder that affects an
estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic …