A Totaro, T Panciera, S Piccolo - Nature cell biology, 2018 - nature.com
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
X Cai, KC Wang, Z Meng - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and homeostasis. During organ development and tissue injury repair, compressive and tensional …
To perceive their three-dimensional environment, cells and tissues must be able to sense and interpret various physical forces like shear, tensile, and compression stress. These …
Organ size is controlled by the concerted action of biochemical and physical processes. Although mechanical forces are known to regulate cell and tissue behavior, as well as …
G Halder, S Dupont, S Piccolo - Nature reviews Molecular cell biology, 2012 - nature.com
The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and …
M Fischer, P Rikeit, P Knaus, C Coirault - Frontiers in physiology, 2016 - frontiersin.org
Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined …
Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined …
A Elbediwy, ZI Vincent‐Mistiaen, BJ Thompson - Bioessays, 2016 - Wiley Online Library
The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear …
Innate immune cells are responsible for eliminating foreign infectious agents and cellular debris, and their ability to perceive, respond to, and integrate biochemical and mechanical …