Childhood maltreatment represents a significant risk factor for the development of a number
of mental and physical health outcomes. Converging evidence suggests that early adversity …

Maltreatment adversely impacts the development of children across a host of domains. One
way in which maltreatment may exert its deleterious effects is by becoming embedded in the …

The neurobiological mechanisms by which childhood maltreatment heightens vulnerability
to psychopathology remain poorly understood. It is likely that a complex interaction between …

Alterations in hypothalamic–pituitary–adrenal (HPA) axis and its effector hormone cortisol
have been proposed as one possible mechanism linking child maltreatment experiences to …

A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

Neglect is a common and frequently chronic form of child maltreatment that can compromise
child development and increase the risk of physical and psychological problems. In this …

Objective Child maltreatment is associated with dysregulation of stress-mediating systems
and an increased risk of mental and physical health problems. Specifically, disruptions in …

There is a relative consensus about the detrimental impact of childhood maltreatment on
later mental health problems and behavioral difficulties. Prior research suggests that …

Prior research has found inconsistent evidence regarding the association among childhood
adversity, inflammation, and internalizing symptoms, perhaps because previous studies …

How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …