Long noncoding RNAs: molecular modalities to organismal functions

JL Rinn, HY Chang - Annual review of biochemistry, 2020 - annualreviews.org
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …

Unique features of long non-coding RNA biogenesis and function

JJ Quinn, HY Chang - Nature reviews genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Long noncoding RNAs: past, present, and future

JTY Kung, D Colognori, JT Lee - Genetics, 2013 - academic.oup.com
Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

VA Moran, RJ Perera, AM Khalil - Nucleic acids research, 2012 - academic.oup.com
The recent discovery that the human and other mammalian genomes produce thousands of
long non-coding RNAs (lncRNAs) raises many fascinating questions. These mRNA-like …

Genome regulation by long noncoding RNAs

JL Rinn, HY Chang - Annual review of biochemistry, 2012 - annualreviews.org
The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

Technologies to probe functions and mechanisms of long noncoding RNAs

C Chu, RC Spitale, HY Chang - Nature structural & molecular biology, 2015 - nature.com
Thousands of long noncoding RNAs (lncRNAs) have been discovered, but their functional
characterization has been slowed by a limited set of research tools. Here we review …

Molecular mechanisms of long noncoding RNAs

KC Wang, HY Chang - Molecular cell, 2011 - cell.com
Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …

The specificity of long noncoding RNA expression

BS Gloss, ME Dinger - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Over the last decade, long noncoding RNAs (lncRNAs) have emerged as a fundamental
molecular class whose members play pivotal roles in the regulation of the genome. The …

Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Rise of the RNA machines: exploring the structure of long non-coding RNAs

IV Novikova, SP Hennelly, CS Tung… - Journal of molecular …, 2013 - Elsevier
Novel, profound and unexpected roles of long non-coding RNAs (lncRNAs) are emerging in
critical aspects of gene regulation. Thousands of lncRNAs have been recently discovered in …