SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals

SI Richardson, VS Madzorera, H Spencer… - Cell Host & Microbe, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …

Considerable escape of SARS-CoV-2 variant Omicron to antibody neutralization

D Planas, N Saunders, P Maes, F Guivel-Benhassine… - BioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 Omicron variant was first identified in November 2021 in Botswana and
South Africa,. It has in the meantime spread to many countries and is expected to rapidly …

SARS-CoV-2 T cell responses elicited by COVID-19 vaccines or infection are expected to remain robust against Omicron

SF Ahmed, AA Quadeer, MR McKay - Viruses, 2022 - mdpi.com
Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple
mutations in the spike protein that were not observed in previous VOCs. Initial studies …

Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

YC Bartsch, X Tong, J Kang, MJ Avendaño… - Science translational …, 2022 - science.org
The Omicron variant of SARS-CoV-2 has been shown to evade neutralizing antibodies
elicited by vaccination or infection. Despite the global spread of the Omicron variant, even …

Different neutralization profiles after primary SARS-CoV-2 Omicron BA. 1 and BA. 2 infections

I Medits, DN Springer, M Graninger, JV Camp… - Frontiers in …, 2022 - frontiersin.org
Background and Methods The SARS-CoV-2 (severe acute respiratory syndrome
coronavirus 2) Omicron (B. 1.1. 529) variant is the antigenically most distinct variant to date …

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

RK Suryawanshi, IP Chen, T Ma, AM Syed, N Brazer… - Nature, 2022 - nature.com
Abstract SARS-CoV-2 Delta and Omicron are globally relevant variants of concern. Although
individuals infected with Delta are at risk of developing severe lung disease, infection with …

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

T Tada, H Zhou, BM Dcosta, MI Samanovic… - …, 2022 - thelancet.com
Background SARS-CoV-2 vaccines currently authorized for emergency use have been
highly successful in preventing infection and lessening disease severity. The vaccines …

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

CH GeurtsvanKessel, D Geers, KS Schmitz… - Science …, 2022 - science.org
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …

Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection

J Zou, H Xia, X Xie, C Kurhade, RRG Machado… - Nature …, 2022 - nature.com
The spread of the Omicron SARS-CoV-2 variant underscores the importance of analyzing
the cross-protection from previous non-Omicron infection. We have developed a high …

Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations

H Jacobsen, M Strengert, H Maaß, MA Ynga Durand… - Scientific reports, 2022 - nature.com
SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to
vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron …