Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression
HJ Shan, WX Gu, G Duan, HL Chen - Bioengineered, 2022 - Taylor & Francis
ARSTRACT N6-methyladenosine (m6A) methylation is the most common and abundant
methylation modification of eukaryotic mRNAs, which is involved in tumor initiation and …
methylation modification of eukaryotic mRNAs, which is involved in tumor initiation and …
Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by …
K Wei, Y Gao, B Wang, YX Qu - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) is one of the most significant modifications in
human mRNAs. Emerging evidence indicates that m6A participates in the initiation and …
human mRNAs. Emerging evidence indicates that m6A participates in the initiation and …
ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner
Z Yang, Z Cai, C Yang, Z Luo, X Bao - EBioMedicine, 2022 - thelancet.com
Summary Background N6-methyladenosine (m6A) is the most common and abundant
mRNA modification and it plays crucial roles in many biological processes. However, as a …
mRNA modification and it plays crucial roles in many biological processes. However, as a …
FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner
A Xu, J Zhang, L Zuo, H Yan, L Chen, F Zhao, F Fan… - Molecular Therapy, 2022 - cell.com
N 6-methyladenosine (m 6 A), as the most pervasive internal modification of eukaryotic
mRNA, plays a crucial role in various cancers, but its role in multiple myeloma (MM) …
mRNA, plays a crucial role in various cancers, but its role in multiple myeloma (MM) …
m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2
W Wang, Y He, LL Zhai, LJ Chen, LC Yao, L Wu… - Epigenetics, 2022 - Taylor & Francis
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …
FTO-stabilized miR-139–5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway
B Azhati, A Reheman, D Dilixiati, M Rexiati - Archives of Biochemistry and …, 2023 - Elsevier
As one of the most important demethylases for RNA N6-methyladenosine (m6A)
modifications, fat mass and obesity-associated protein (FTO) plays anti-cancer role during …
modifications, fat mass and obesity-associated protein (FTO) plays anti-cancer role during …
Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance …
M Ye, J Chen, F Lu, M Zhao, S Wu, C Hu, P Yu, J Kan… - Cell & Bioscience, 2023 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most abundant
reversible methylation modification in eukaryotes, and it is reportedly closely associated with …
reversible methylation modification in eukaryotes, and it is reportedly closely associated with …
The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1
W Miao, J Chen, L Jia, J Ma, D Song - Biochemical and biophysical …, 2019 - Elsevier
Osteosarcoma (OS) is the most common and aggressive malignant bone sarcoma, which
occurs in rapidly growing bones in children and adolescents. However, the underlying …
occurs in rapidly growing bones in children and adolescents. However, the underlying …
N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis
Z Ren, Y Hu, J Sun, Y Kang, G Li, H Zhao - Bioengineered, 2022 - Taylor & Francis
Long noncoding RNAs (lncRNAs) play critical roles in tumor progression regulation,
including osteosarcoma. Evidence indicates that N6-methyladenosine (m6A) modification …
including osteosarcoma. Evidence indicates that N6-methyladenosine (m6A) modification …
[HTML][HTML] m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation
J Li, L Zhu, Y Shi, J Liu, L Lin… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …