Western diet-induced obesity is linked to the development of metabolic dysfunctions,
including type 2 diabetes and complications that include retinopathy, a leading cause of …

Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans.
Clinicians diagnose DR based on its characteristic vascular pathology, which is evident …

We have shown previously that diabetes causes increases in retinal arginase activity that
are associated with impairment of endothelial cell (EC)-dependent vasodilation and …

Aims/hypothesis A reduction in retinal blood flow occurs early in diabetes and is likely to be
involved in the development of diabetic retinopathy. We hypothesise that activation of the …

Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key
components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase …

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major
clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 …

Objective Retinal ischemic disease is a major cause of vision loss. Current treatment options
are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not …

Optic neuritis is a major clinical feature of multiple sclerosis (MS) and can lead to temporary
or permanent vision loss. Previous studies from our laboratory have demonstrated the …

Background Macrophage‐mediated chronic inflammation is mechanistically linked to insulin
resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role …

Current therapies for treatment of proliferative retinopathy focus on retinal
neovascularization (RNV) during advanced disease and can trigger adverse side-effects …