Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by
several species of parasites belonging to the family Trypansomatida. The present study …

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal
agents. All tested compounds caused concentration-dependent inhibition of the in vitro …

Bioactivity-guided fractionation of the methanolic extract of Psorothamnus polydenius
yielded the new chalcone 2, 2 ', 4 '-trihydroxy-6 '-methoxy-3 ', 5 '-dimethylchalcone (2) …

A variety of chalcones have been shown to exhibit activity against Leishmania parasites. In
contrast to synthetic or semisynthetic chalcones, only a few plant‐derived compounds have …

The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the
hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is …

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis
axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with …

The purpose of this study is to evaluate the toxicity of synthetic chalcones 1 and 2 in
uninfected hamsters and anti-Leishmania activity of synthetic chalcones 1 and 2 in hamsters …

The available drugs for treating Leishmaniasis and American trypanosomiasis have high
toxicity and multiple side effects, among other problems. More effective and less toxic …

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian
medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive …

Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among
them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity …