Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are
chronic intestinal disorders, which are on the increase in “Westernised” countries. IBD can …

In recent years it has become clear that chronic inflammatory bowel disease (IBD),
especially Crohn's disease (CD), is caused by a loss of tolerance against the autologous …

BACKGROUND & AIMS: Interleukin 10 (IL-10) is a cytokine with immunosuppressive and
anti-inflammatory activities. Gene-targeted IL-10-deficient mice develop a chronic intestinal …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are
chronic inflammatory disorders of gastrointestinal tract. Although the etiology is incompletely …

Background & Aims: Interleukin (IL)-10 is a cytokine with potent anti-inflammatory properties.
We investigated the safety and efficacy of different doses of human recombinant (rhu) IL-10 …

IL-10-deficient mice exhibit spontaneous enterocolitis and other symptoms akin to Crohn's
disease, indicating that IL-10 might regulate normal physiology in the gut. However, clinical …

Background The etiology of Crohn's disease remains unknown, nevertheless, it is apparent
that inflammation is associated with an imbalance between proinflammatory and anti …

Background & Aims: Interleukin 10 (IL-10) is an anti-inflammatory, immunomodulatory
cytokine that regulates mucosal inflammation. This study evaluated the safety, tolerance …

The gastrointestinal tract serves as a barrier between the host and the vast array of foreign
antigens that are contained within its lumen. The mucosal immune system must balance two …

Twenty years ago, the observation that mice genetically deficient in IL-10 spontaneously
developed severe intestinal inflammation, revealed an essential role for IL-10 in the …