The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence
implicates a role for defective calcium reabsorption in the renal proximal tubule. We …

Claudins are discovered to be key players in renal epithelial physiology. They are involved
in developmental, physiological, and pathophysiological differentiation. In the glomerular …

The renal proximal tubule (PT) is responsible for the reabsorption of approximately 65% of
filtered calcium, primarily via a paracellular pathway. However, which protein (s) contribute …

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal
absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re) absorption …

Claudins are tight-junction membrane proteins that function as both pores and barriers in the
paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability …

The tight junction proteins claudin-10 and-16 are crucial for the paracellular reabsorption of
cations along the thick ascending limb of Henle's loop in the kidney. In patients, mutations in …

Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial
cells. In the mammalian kidney, every tubular segment express a specific set of claudins that …

Mutations in the gene coding for the renal tight junction protein claudin 16 cause familial
hypomagnesemia with hypercalciuria and nephrocalcinosis, an autosomal recessive …

Claudins are tight junction membrane proteins that regulate paracellular permeability of
renal epithelia to small ions, solutes, and water. Claudins interact within the cell membrane …

Claudin-7, a member of the claudin family, is highly expressed in distal nephrons of kidneys
and has been reported to be involved in the regulation of paracellular Cl− permeability in …