Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
[PDF][PDF] Decay of Fc-dependent antibody functions after mild to moderate COVID-19
The capacity of antibodies to engage with immune cells via the Fc region is important in
preventing and controlling many infectious diseases. The evolution of such antibodies …
preventing and controlling many infectious diseases. The evolution of such antibodies …
[PDF][PDF] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …
[PDF][PDF] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
Dissecting antibody-mediated protection against SARS-CoV-2
T Zohar, G Alter - Nature Reviews Immunology, 2020 - nature.com
Understanding the properties and mechanisms by which antibodies provide protection is
essential to defining immunity. Although neutralizing antibodies have been proposed as a …
essential to defining immunity. Although neutralizing antibodies have been proposed as a …
COVID-19 severity is associated with differential antibody Fc-mediated innate immune functions
Beyond neutralization, antibodies binding to their Fc receptors elicit several innate immune
functions including antibody-dependent complement deposition (ADCD), antibody …
functions including antibody-dependent complement deposition (ADCD), antibody …
Waning and boosting of antibody Fc-effector functions upon SARS-CoV-2 vaccination
X Tong, RP McNamara, MJ Avendaño… - Nature …, 2023 - nature.com
Since the emergence of SARS-CoV-2, vaccines targeting COVID-19 have been developed
with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form of the …
with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form of the …
The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates
Summary SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19, making
them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …
them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
SARS-CoV-2, the causative agent of COVID-19, has been responsible for over 42 million
infections and 1 million deaths since its emergence in December 2019. There are few …
infections and 1 million deaths since its emergence in December 2019. There are few …