Rational selection of individual adjuvants can often be made on the basis of innate
molecular interactions of the foreign molecules with pattern recognition receptors such as …

New generation vaccines, particularly those based on recombinant proteins and DNA, are
likely to be less reactogenic than traditional vaccines but are also less immunogenic …

The development of new adjuvants for human vaccines has become an expanding field of
research in the last thirty years, for generating stronger vaccines capable of inducing …

Vaccine adjuvants interact with the immune system, to increase the potency of vaccine
antigens. Many of the adjuvants currently available were developed with little understanding …

Despite the important role of adjuvants for vaccine development, relatively few adjuvants
have been successfully incorporated into vaccines intended for human administration. This …

A clear understanding of the mechanism of function of immune stimulatory adjuvants, which
commonly accompany vaccines, is beginning to emerge. Recent investigations have …

Toll-like receptor (TLR) agonists are being developed for use as vaccine adjuvants and as
stand-alone immunomodulators because of their ability to stimulate innate and adaptive …

Adjuvants help antigen to elicit an early, high and long-lasting immune response with less
antigen, thus saving on vaccine production costs. In recent years, adjuvants received much …

Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact
vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In …

Abstract Formulation science is an unappreciated and often overlooked aspect in the field of
vaccinology. In this review we highlight key attributes necessary to generate well …