Transcriptomics data are relevant to address a number of challenges in Toxicogenomics
(TGx). After careful planning of exposure conditions and data preprocessing, the TGx data …

Preprocessing of transcriptomics data plays a pivotal role in the development of
toxicogenomics-driven tools for chemical toxicity assessment. The generation and …

The starting point of successful hazard assessment is the generation of unbiased and
trustworthy data. Conventional toxicity testing deals with extensive observations of …

Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible
toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to …

The recent advancements in toxicogenomics have led to the availability of large omics data
sets, representing the starting point for studying the exposure mechanism of action and …

The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in
order to study systems-level responses to compound treatments. In recent years there has …

It is still a major challenge to protect humans at workplaces and in the environment. To cope
with this task, it is a prerequisite to obtain detailed information on the extent of chemical …

Toxicogenomics (TGx) has contributed significantly to toxicology and now has great
potential to support moves towards animal-free approaches in regulatory decision making …

One of the major challenges in realization and implementations of the Tox21 vision is the
urgent need to establish quantitative link between in-vitro assay molecular endpoint and in …

Although microarray technology has emerged as a powerful tool to explore expression
levels of thousands of genes or even complete genomes after exposure to toxicants, the …