Methionine is an aliphatic, sulfur-containing, essential amino acid that has been
demonstrated to have crucial roles in metabolism, innate immunity, and activation of …

Manganese (Mn) is a trace element involved in many physiological processes. However,
excessive Mn exposure leads to neurological complications. Although no precise …

Reactive oxygen species (ROS) is reported to be a critical pathogenic factor and
mitochondria is one of the susceptible subcellular organs for oxidative damage. Methionine …

Background Parkinson's disease (PD) is a multifactorial movement disorder with the
progressive degeneration of the nigrostriatal system that impairs patients' movement ability …

Background L-methionine, the principal sulfur-containing amino acid in proteins, plays
critical roles in cell physiology as an antioxidant and in the breakdown of fats and heavy …

Abstract Aim Hyperhomocysteinemia and homocysteine (Hcy) mediated dopaminergic
neurotoxicity is a matter of concern in the pathophysiology of Parkinson's disease (PD). Our …

Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder after Alzheimer's disease. Pathophysiologically, it is characterized by …

We propose that elevation of mitochondrial enzyme cofactors may prevent or ameliorate
neurodegenerative diseases by improving mitochondrial function. In the present study, we …

Parkinson's disease (PD), a common neurodegenerative disease, is caused by loss of
dopaminergic neurons in the substantia nigra. Although the underlying cause of the …

Diets high in methionine lead to elevation of plasma homocysteine levels which are possibly
linked to neurodegenerative diseases and oxidative stress. In the present study, we …