High-CBD cannabis extracts inhibit the expression of proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cells
The incidence of chronic inflammatory disorders and autoimmune diseases is rapidly
growing. To date, the COVID-19 pandemic caused by SARS-CoV-2 has killed over …
growing. To date, the COVID-19 pandemic caused by SARS-CoV-2 has killed over …
New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts
B Wang, D Li, A Fiselier, I Kovalchuk… - Cell death …, 2022 - nature.com
COVID-19 is caused by the SARS-CoV-2 virus, which enters target cells via interactions with
ACE2 and TMPRSS2. Here, we show AKT serine/threonine kinase-dependent epigenetic …
ACE2 and TMPRSS2. Here, we show AKT serine/threonine kinase-dependent epigenetic …
Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages
SM Anil, N Shalev, AC Vinayaka, S Nadarajan… - Scientific reports, 2021 - nature.com
Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity. This
study intended to examine the anti-inflammatory activity of cannabis on immune response …
study intended to examine the anti-inflammatory activity of cannabis on immune response …
[HTML][HTML] In search of preventative strategies: novel anti-inflammatory high-CBD cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues
With the rapidly growing pandemic of COVID-19 caused by the new and challenging to treat
zoonotic SARS-CoV2 coronavirus, there is an urgent need for new therapies and prevention …
zoonotic SARS-CoV2 coronavirus, there is an urgent need for new therapies and prevention …
[HTML][HTML] In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues
B Wang, A Kovalchuk, D Li, R Rodriguez-Juarez… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
With the current COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), there is an urgent need for new therapies and prevention …
coronavirus 2 (SARS-CoV-2), there is an urgent need for new therapies and prevention …
Cannabinoids alleviate the LPS-induced cytokine storm via attenuating NLRP3 inflammasome signaling and TYK2-mediated STAT3 signaling pathways in vitro
SV Suryavanshi, M Zaiachuk, N Pryimak, I Kovalchuk… - Cells, 2022 - mdpi.com
Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …
studied group of compounds obtained from Cannabis sativa because of their several …
Phytocannabinoids Reduce Inflammation of Primed Macrophages and Enteric Glial Cells: An In Vitro Study
G Cohen, O Gover, B Schwartz - International Journal of Molecular …, 2023 - mdpi.com
Intestinal inflammation is mediated by a subset of cells populating the intestine, such as
enteric glial cells (EGC) and macrophages. Different studies indicate that phytocannabinoids …
enteric glial cells (EGC) and macrophages. Different studies indicate that phytocannabinoids …
Cannabidiol inhibits SARS‐Cov‐2 spike (S) protein‐induced cytotoxicity and inflammation through a PPARγ‐dependent TLR4/NLRP3/Caspase‐1 signaling …
C Corpetti, A Del Re, L Seguella, I Palenca… - Phytotherapy …, 2021 - Wiley Online Library
Given the abundancy of angiotensin converting enzyme 2 (ACE‐2) receptors density,
beyond the lung, the intestine is considered as an alternative site of infection and replication …
beyond the lung, the intestine is considered as an alternative site of infection and replication …
Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator
S Wang, Q Luo, P Fan - International Journal of Molecular Sciences, 2019 - mdpi.com
Hemp seed (Fructus cannabis) is rich in lignanamides, and initial biological screening tests
showed their potential anti-inflammatory and anti-oxidative capacity. This study investigated …
showed their potential anti-inflammatory and anti-oxidative capacity. This study investigated …
Cannabidiol modulates cytokine storm in acute respiratory distress syndrome induced by simulated viral infection using synthetic RNA
Introduction: In the absence of effective antivirals and vaccination, the pandemic of COVID-
19 remains the most significant challenge to our health care system in decades. There is an …
19 remains the most significant challenge to our health care system in decades. There is an …