Pathophysiology and treatment of stroke: present status and future perspectives

D Kuriakose, Z Xiao - International journal of molecular sciences, 2020 - mdpi.com
Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

The development of novel drug treatments for stroke patients: a review

D Frank, A Zlotnik, M Boyko… - International Journal of …, 2022 - mdpi.com
Acute ischemic stroke is a critical condition that can result in disability and death. The
consequences of this medical condition depend on various factors, including the size of the …

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Stroke: molecular mechanisms and potential targets for treatment

Z Zheng, JE Lee, MA Yenari - Current Molecular Medicine, 2003 - ingentaconnect.com
Significant advances have been made over the past few years concerning the cellular and
molecular events underlying ischemic cell death. The brain succumbs to ischemic injury as a …

Stroke: Molecular mechanisms and therapies: Update on recent developments

F Shehjar, B Maktabi, ZA Rahman, GA Bahader… - Neurochemistry …, 2023 - Elsevier
Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …

[PDF][PDF] Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics

E Candelario-Jalil - Curr Opin Investig Drugs, 2009 - researchgate.net
Ischemic stroke triggers a complex and highly interconnected cascade of cellular and
molecular events. Early events induced following ischemic injury, including excitotoxicity …

Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis

P Deb, S Sharma, KM Hassan - Pathophysiology, 2010 - Elsevier
Stroke is a serious neurological disease, and constitutes a major cause of death and
disability throughout the world. The pathophysiology of stroke is complex, and involves …

Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment

Y Zhao, X Zhang, X Chen… - … journal of molecular …, 2022 - spandidos-publications.com
Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …

A review on animal models of stroke: an update

A Kumar, V Gupta - Brain research bulletin, 2016 - Elsevier
Stroke is one of the major healthcare challenges prevailing across the globe due to its
significant rate of mortality and morbidity. Stroke is multifactorial in nature and involves …

The science of stroke: mechanisms in search of treatments

MA Moskowitz, EH Lo, C Iadecola - Neuron, 2010 - cell.com
This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …