Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes
J Schwartzentruber, S Cooper, JZ Liu… - Nature …, 2021 - nature.com
Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
Whole‐genome sequencing reveals new Alzheimer's disease–associated rare variants in loci related to synaptic function and neuronal development
D Prokopenko, SL Morgan, K Mullin… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Genome‐wide association studies have led to numerous genetic loci
associated with Alzheimer's disease (AD). Whole‐genome sequencing (WGS) now permits …
associated with Alzheimer's disease (AD). Whole‐genome sequencing (WGS) now permits …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
An overview of genome-wide association studies in Alzheimer's disease
L Shen, J Jia - Neuroscience bulletin, 2016 - Springer
Genome-wide association studies (GWASs) have revealed a plethora of putative
susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene …
susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene …
New insights on the genetic etiology of Alzheimer's and related dementia
C Bellenguez, F Küçükali, I Jansen, V Andrade… - MedRxiv, 2020 - medrxiv.org
Deciphering the genetic landscape of Alzheimer's disease (AD) is essential to define the
pathophysiological pathways involved and to successfully translate genomics to potential …
pathophysiological pathways involved and to successfully translate genomics to potential …
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …
reported genome-wide significant loci do not account for all the estimated heritability and …