Glutamine synthetase (GS) is an ATP-dependent enzyme found in most species that
synthesizes glutamine from glutamate and ammonia. In brain, GS is exclusively located in …

Abstract Glutamine synthetase (GS, EC 6.3. 1.2) is a ubiquitous and highly
compartmentalized enzyme that is critically involved in several metabolic pathways in the …

The multifunctional properties of astrocytes signify their importance in brain physiology and
neurological function. In addition to defining the brain architecture, astrocytes are primary …

Although the role of astrocyte glutamate transporters in glutamate clearance is well
illustrated, the role of glutamine synthetase (GS) that influences this process remains to be …

Glutamine synthetase (GS) in brain is located mainly in astrocytes. One of the primary roles
of astrocytes is to protect neurons against excitotoxicity by taking up excess ammonia and …

Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that
catalyses the synthesis of glutamine by condensing ammonium to glutamate. In the …

Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the
neurological sequelae following severe liver disease. Ammonia is cleared via two main …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Glutamate-ammonia ligase (glutamine synthetase; Glul) is enriched in astrocytes and serves
as the primary enzyme for ammonia detoxification and glutamate inactivation in the brain …

Regulation of glutamate metabolism via glutamate dehydrogenase (GDH) might be the
promising therapeutic approach for treating neurodegenerative disorders. In the central …