Resistance to commercially available antimalarial drugs is a public health problem. Since
the end of the last century, no new antimalarial drugs have been introduced into clinical …

Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and
drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great …

A convenient approach to antimalarial drug discovery is the use of the organic scaffold of a
known antimalarial drug and an organometallic moiety to alter its unwanted properties …

To establish the role of the ferrocenyl moiety in the antiplasmodial activity of ferroquine,
compounds in which this moiety is replaced by the corresponding ruthenium-based moieties …

Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …

Malaria has been teasing human populations from a long time. Presently, several classes of
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …

Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

The antimalarial activities of ferrocenic compounds mimicking chloroquine and active upon
chloroquine-resistant strains of Plasmodium falciparum were evaluated. Four 7-chloro-4-[[[2 …

Five compounds displaying an unprecedented binding mode of chloroquine to ferrocene
through the bridging of the cyclopentadienyl rings were studied alongside their …