The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Various intracellular pattern recognition receptors (PRRs) recognize cytosolic pathogen-
associated molecular patterns (PAMPs) and damage-associated molecular patterns …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …

BACKGROUND The life of any organism depends on the ability of cells to accurately
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …

SnapShot: CGAS-STING Signaling Page 1 3 Cell ???, ??MONTH?? ??DATE??, 200? ©200?
Elsevier Inc. DOI XXXXXXXXX See online version for ??????. S n a pS h o t: XXX X X X XX …

Summary cGAS-STING signaling is essential for innate immunity. Its misregulation promotes
cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify …

The cGAS STING pathway has received much attention in recent years, and it has been
recognized as an important component of the innate immune response. Since the discovery …