A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity

X Chen, S Zhi, X Han, J Jiang, G Liu, S Rao - Journal of Translational …, 2024 - Springer
Abstract Background Allergic diseases (ADs) such as asthma are presumed risk factors for
COVID-19 infection. However, recent observational studies suggest that the assumed …

Allergic disease as a causal protective factor for severe covid-19: a multivariable mendelian randomization study

Q Lu, Y Yu - Authorea Preprints, 2023 - authorea.com
Allergic diseases were recently reported related to both SARS-CoV-2 infection and severe
COVID-19 through observational studies. However, their causal relationship remains …

Causal association and shared genetics between asthma and COVID-19

A Baranova, H Cao, J Chen, F Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Objectives Recent studies suggest that asthma may have a protective effect on COVID-19.
We aimed to investigate the causality between asthma and two COVID-19 outcomes and …

Conventional dendritic cell 2 links the genetic causal association from allergic asthma to COVID-19: a Mendelian randomization and transcriptomic study

H Liu, S Huang, L Yang, H Zhou, B Chen, L Wu… - Journal of Big Data, 2024 - Springer
Recent evidence suggests that allergic asthma (AA) decreases the risk of Coronavirus
Disease 2019 (COVID-19). However, the reasons remain unclear. Here, we systematically …

Exploring genetic associations between allergic diseases and indicators of COVID-19 using mendelian randomization

Y Wang, X Gu, X Wang, W Zhu, J Su - Iscience, 2023 - cell.com
We carried out a bidirectional Mendelian randomization (MR) including cases of eczema
(N= 218,792), asthma (N= 462,933), and allergic rhinitis (N= 112,583). COVID-19 …

Non-causal effects of asthma on COVID-19 susceptibility and severity

LJ Qiu, KJ Yin, GX Pan, J Ni, B Wang - Frontiers in Genetics, 2022 - frontiersin.org
Background: Asthma is observationally associated with an increased risk of COVID-19, but
the causality remains unclear. We aim to determine whether there is a casual role of asthma …

Genomic analysis of severe COVID-19 considering or not asthma comorbidity: GWAS insights from the BQC19 cohort

O Amri, AM Madore, AM Boucher-Lafleur, C Laprise - BMC genomics, 2024 - Springer
Background The severity of COVID-19 is influenced by various factors including the
presence of respiratory diseases. Studies have indicated a potential relationship between …

Association of asthma and its genetic predisposition with the risk of severe COVID-19

Z Zhu, K Hasegawa, B Ma, M Fujiogi… - Journal of Allergy and …, 2020 - jacionline.org
To the Editor: In individuals with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection, the severity of illness ranges from asymptomatic to fatal. 1 The Centers for …

Asthma may not be a potential risk factor for severe COVID-19 illness: a scoping review

CS Ubah, GD Kearney… - Environmental Health …, 2024 - journals.sagepub.com
The coronavirus disease 2019 (COVID-19) is a respiratory disease caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), but whether the asthmatic patients are …

Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders

MA Waszczuk, O Morozova, E Lhuillier, AR Docherty… - Plos one, 2023 - journals.plos.org
Background Genetic factors contribute to individual differences in the severity of coronavirus
disease 2019 (COVID-19). A portion of genetic predisposition can be captured using …