Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

L Wang, T Zhou, Y Zhang, ES Yang, CA Schramm… - Science, 2021 - science.org
INTRODUCTION Worldwide appearance of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) variants of concern (VOCs) with increased transmissibility and resistance to …

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

SM Reincke, M Yuan, HC Kornau, VM Corman… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Beta variant of concern
(VOC) resists neutralization by major classes of antibodies from COVID-19 patients and …

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B. 1.1. 529

T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022 - science.org
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.
1.1. 529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent …

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

PJM Brouwer, TG Caniels, K van der Straten… - Science, 2020 - science.org
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …

Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

KG Nabel, SA Clark, S Shankar, J Pan, LE Clark… - Science, 2021 - science.org
Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant …

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection

J Guenthoer, M Lilly, TN Starr… - Proceedings of the …, 2023 - National Acad Sciences
The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

W He, R Musharrafieh, G Song, K Dueker, LV Tse… - Nature …, 2022 - nature.com
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …

[PDF][PDF] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - Immunity, 2021 - cell.com
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …

[HTML][HTML] Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Antibodies elicited in response to infection undergo somatic mutation in germinal centers
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …