Selectivity of interactions between nanoparticles functionalized by tethered ligands and cell
surfaces with different densities of receptors plays an essential role in biorecognition and its …

Nanoparticles functionalized with multiple ligands can be programed to bind biological
targets depending on the receptors they express, providing a general mechanism exploited …

Using Monte Carlo simulations, we analyze the efficiency in targeting mobile receptors on
cell surfaces by nanoparticles carrying multivalent (divalent, tetravalent) ligands. We show …

In receptor-mediated endocytosis, cells exercise biochemical control over the mechanics of
adhesion to engulf foreign particles, featuring a variable adhesion strength. Here we present …

A key challenge in nano-science is to design ligand-coated nano-particles that can bind
selectively to surfaces that display the cognate receptors above a threshold (surface) …

Receptor-mediated targeting of nanometric contrast agents or drug carriers holds great
potential for treating cardiovascular and vascular-associated diseases. However, predicting …

Nanoparticles bearing surface-conjugated targeting ligands are increasingly being explored
for a variety of biomedical applications. The multivalent conjugation of targeting ligands on …

Using computer simulations, we systematically studied the influence of different design
parameters of a spherical nanoparticle tethered with monovalent ligands on its efficiency of …

Nanoparticles are increasingly important for biological applications ranging from drug
delivery to cellular imaging. In the course of these applications, nanoparticles are exposed …

We elucidate, from thermodynamic arguments, the governing factors of receptor-mediated
endocytosis of nanoparticles (NPs). We show that the endocytic energetics specifies a …