Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform …

Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …

Cancer evolution determines molecular and morphologic intratumor heterogeneity and
challenges the design of effective treatments. In lung adenocarcinoma, disease progression …

Little is known of the geospatial architecture of individual cell populations in lung
adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of …

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar)
histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but …

Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical
adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally …

Introduction The purpose of the study is to genomically characterize the biology and related
therapeutic opportunities of prognostically important predominant histologic subtypes in lung …

Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …

To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we …