Accumulating evidence has indicated that sirtuins are key components of diverse
physiological processes, including metabolism and aging. Sirtuins confer protection from a …

Aging is accompanied by a decline in the healthy function of multiple organ systems, leading
to increased incidence and mortality from diseases such as type II diabetes mellitus …

Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have many more functions and to be much more abundant in living organisms. The …

Members of the sirtuin family of protein deacetylases support and promote longevity in
diverse organisms and can extend life span when upregulated. Sirtuin pathways also …

Sirtuins are protein factors that can delay aging and alleviate age-related diseases through
multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Sirtuins post-translationally modulate the function of many cellular proteins that undergo
reversible acetylation–deacetylation cycles, affecting physiological responses that have …

Advancing age is the major risk factor for the development of chronic diseases and is
accompanied by changes in metabolic processes and mitochondrial dysfunction …

Sirtuin proteins are conserved regulators of aging that have recently emerged as important
modifiers of several diseases which commonly occur later in life such as cancer, diabetes …

The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …