Introduction Recent advances in human cardiac 3D approaches have yielded progressively
more complex and physiologically relevant culture systems. However, their application in the …

Ex vivo modelling systems for cardiovascular research are becoming increasingly important
in reducing lab animal use and boosting personalized medicine approaches. Integrating …

Background Cardiac fibrosis is the most common pathway of many cardiac diseases. To
date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic …

Cardiomyocytes and endothelial cells in the heart are in close proximity and in constant
dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium …

Cardiac fibrosis represents a serious clinical problem. Development of novel treatment
strategies is currently restricted by the lack of the relevant experimental models in a human …

As a result of stress, injury, or aging, cardiac fibrosis is characterized by excessive
deposition of extracellular matrix (ECM) components resulting in pathological remodeling …

Rationale: Activated fibroblasts are the major cell type that secretes excessive extracellular
matrix in response to injury, contributing to pathological fibrosis and leading to organ failure …

Cardiac fibroblasts play an essential role in the development of the heart and are implicated
in disease progression in the context of fibrosis and regeneration. Here, we establish a …

Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Due to the integration of recent advances in stem cell biology, materials science, and
engineering, the field of cardiac tissue engineering has been rapidly progressing toward …