Ischemic stroke causes blood–brain barrier (BBB) breakdown due to significant damage to
the integrity of BBB components. Recent studies have highlighted the importance of …

Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement
membranes (BMs) during vasculogenesis. In the present study we have investigated vessel …

The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular
endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB …

Post-stroke functional recovery can occur spontaneously during the subacute phase;
however, how post-stroke fibrotic repair affects functional recovery is highly debated. Platelet …

Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of
vascular pericytes into ischemic lesion to restore the blood-brain barrier (BBB) dysfunction …

Post-stroke intra-infarct repair promotes peri-infarct neural reorganization leading to
functional recovery. Herein, we examined the remodeling of extracellular matrix proteins …

Background and Purpose: Poststroke tissue repair, comprised of macrophage-mediated
clearance of myelin debris and pericyte-mediated fibrotic response within the infarct area, is …

Neurons in the penumbra (the area surrounding ischemic tissue that consists of still viable
tissue but with reduced blood flow and oxygen transport) may be rescued following stroke if …

The cerebral microvasculature is important for maintaining brain homeostasis. This is
achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized …

Disruption of the blood-brain barrier (BBB) integrity occurring during the early onset of stroke
is not only a consequence of, but also contributes to the further progression of stroke …