The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence

I Sá-Correia, S Tenreiro - Journal of biotechnology, 2002 - Elsevier
The emergence of multidrug resistance (MDR) plays a crucial role in the failure of treatments
of tumors and infectious diseases and in the control of plant pathogens, weeds and food …

[HTML][HTML] MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post …

SC Dos Santos, MC Teixeira, PJ Dias… - Frontiers in …, 2014 - frontiersin.org
Multidrug/Multixenobiotic resistance (MDR/MXR) is a widespread phenomenon with clinical,
agricultural and biotechnological implications, where MDR/MXR transporters that are …

Drug: H+ antiporters in chemical stress response in yeast

I Sá-Correia, SC dos Santos, MC Teixeira… - Trends in …, 2009 - cell.com
The emergence of widespread multidrug resistance (MDR) is a serious challenge for
therapeutics, food-preservation and crop protection. Frequently, MDR is a result of the action …

Evolution of the 12-spanner drug: H+ antiporter DHA1 family in hemiascomycetous yeasts

PJ Dias, ML Seret, A Goffeau, IS Correia… - Omics: a journal of …, 2010 - liebertpub.com
Frequently, although not exclusively, multidrug resistance (MDR) results from the action of
drug-efflux pumps, which are thought to be able to catalyze the active expulsion of several …

Evolution of gene families: the multidrug resistance transporter genes in five related yeast species

Y Gbelska, JJ Krijger, KD Breunig - FEMS yeast research, 2006 - academic.oup.com
The available genomic sequences of five closely related hemiascomycetous yeast species
(Kluyveromyces lactis, Kluyveromyces waltii, Candida glabrata, Ashbya (Eremothecium) …

Multidrug‐resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames within the major facilitator …

A Goffeau, J Park, IT Paulsen, JLUC JONNIAUX… - Yeast, 1997 - Wiley Online Library
Screening of the complete genome sequence from the yeast Saccharomyces cerevisiae
reveals that 28 open reading frames (ORFs) are homologous to each other and to …

[HTML][HTML] The drug:H+ antiporters of family 2 (DHA2), siderophore transporters (ARN) and glutathione:H+antiporters (GEX) have a common evolutionary origin in …

PJ Dias, I Sá-Correia - BMC genomics, 2013 - Springer
Abstract Background The Saccharomyces cerevisiae 14-spanner Drug: H+ Antiporter family
2 (DHA2) are transporters of the Major Facilitator Superfamily (MFS) involved in multidrug …

Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

M Kolaczkowski, A Goffeau - Pharmacology & therapeutics, 1997 - Elsevier
Mankind is faced by the increasing emergence of resistant pathogens, including cancer
cells. An overview of the different strategies adopted by a variety of cells to evade …

Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters

A Nourani, M Wesolowski-Louvel… - … and cellular biology, 1997 - Am Soc Microbiol
In the yeast Saccharomyces cerevisiae, multidrug resistance to unrelated chemicals can
result from overexpression of ATP-binding cassette (ABC) transporters such as Pdr5p …

Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing

B Nelissen, P Mordant, JL Jonniaux, R De Wachter… - FEBS letters, 1995 - Elsevier
From the approximately 5000 open reading frames presently identified by systematic
sequencing of the yeast genome, 100 Saccharomyces cerevisiae transport proteins …