Influenza A virus (IAV) has evolved various strategies to counteract the innate immune
response using different viral proteins. However, the mechanism is not fully elucidated. In …

Infection with seasonal as well as highly pathogenic avian influenza A virus (IAV) causes
significant morbidity and mortality worldwide. As a major virulence factor, PB1-F2 protein of …

Influenza A virus (IAV) infection induces mitophagy, which is essential for the clearance of
damaged mitochondria. Dysfunctional mitochondria can be selectively targeted by PINK1 …

Influenza A virus (IAV) employs diverse strategies to circumvent type I interferon (IFN)
responses, particularly by inhibiting the synthesis of type I IFNs. However, it is poorly …

Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …

As a major component of the viral ribonucleoprotein (vRNP) complex in influenza A virus
(IAV), nucleoprotein (NP) interacts with isoforms of importin α family members, leading to the …

The ability for a host to recognize infection is critical for virus clearance and often begins with
induction of inflammation. The PB1-F2 of pathogenic influenza A viruses (IAV) contributes to …

Influenza A virus (IAV) utilizes multiple strategies to confront or evade host type I interferon
(IFN)-mediated antiviral responses in order to enhance its own propagation within the host …

The inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs)
during infection, including RNA and proteins from influenza A virus (IAV). However, chronic …

Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …