A synergetic turn in cognitive neuroscience of brain diseases
Despite significant improvements in our understanding of brain diseases, many barriers
remain. Cognitive neuroscience faces four major challenges: complex structure–function …
remain. Cognitive neuroscience faces four major challenges: complex structure–function …
[HTML][HTML] Great expectations: using whole-brain computational connectomics for understanding neuropsychiatric disorders
G Deco, ML Kringelbach - Neuron, 2014 - cell.com
The study of human brain networks with in vivo neuroimaging has given rise to the field of
connectomics, furthered by advances in network science and graph theory informing our …
connectomics, furthered by advances in network science and graph theory informing our …
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
[HTML][HTML] Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness
JW Buckholtz, A Meyer-Lindenberg - Neuron, 2012 - cell.com
The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between …
human experience requires precisely choreographed patterns of interaction between …
Multiscale neuroscience of psychiatric disorders
The human brain comprises a multiscale network with multiple levels of organization.
Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry …
Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry …
Linking brain structure, activity, and cognitive function through computation
Understanding the human brain is a “Grand Challenge” for 21st century research.
Computational approaches enable large and complex datasets to be addressed efficiently …
Computational approaches enable large and complex datasets to be addressed efficiently …
[HTML][HTML] Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease
The brain is composed of disparate neural populations that communicate and interact with
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …
[HTML][HTML] Integrative understanding of emergent brain properties, quantum brain hypotheses, and connectome alterations in dementia are key challenges to conquer …
RO Kuljiš - Frontiers in neurology, 2010 - frontiersin.org
The biological substrate for cognition remains a challenge as much as defining this function
of living beings. Here, we examine some of the difficulties to understand normal and …
of living beings. Here, we examine some of the difficulties to understand normal and …
Modeling neuropsychiatric spectra to empower translational biological psychiatry.
AV Kalueff, AM Stewart - Behavioural brain research, 2015 - psycnet.apa.org
This article provides an overview of the papers presented in the current issue of Behavioural
Brain Research. This is dedicated to neuropsychiatric spectra and 'integrative'modeling of …
Brain Research. This is dedicated to neuropsychiatric spectra and 'integrative'modeling of …
Network models to enhance the translational impact of cross-species studies
Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …
understanding specific aspects of the human condition. However, the translation of findings …