RNA methylation is a critical mechanism for regulating the transcription and translation of
specific sequences or for eliminating unnecessary sequences during RNA maturation …

The RNA methyltransferase METTL3 catalyzes N 6-methyladenosine (m6A) modification of
messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute …

N6-Methyladenosine (m6A) is the most prevalent mRNA modification in mammalian cells
that is mainly catalyzed by the methyltransferase complex of methyltransferase-like 3 and …

The methylase METTL3 is the writer enzyme of the N6‐methyladenosine (m6A) modification
of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor …

The RNA methylase METTL3 catalyzes the transfer of a methyl group from the cofactor S‐
adenosyl‐L‐methionine (SAM) to the N6 atom of adenine. We have screened a library of …

Abstract N 6-methyladenosine (m 6 A) is the most common internal modification of mRNAs
in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like …

A variety of covalent modifications of RNA have been identified and demonstrated to affect
RNA processing, stability, and translation. Methylation of adenosine at the N6 position (m6A) …

Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …

Recently, covalent modifications of RNA, such as methylation, have emerged as key
regulators of all aspects of RNA biology and have been implicated in numerous diseases …

Methyltransferase complex, such as METTL3/METTL14/WTP, catalyze N 6-methyladenosine
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …