Discovered in 1986 as a DNA binding activity that recognized the immunoglobulin light
chain intronic enhancer, NF-κB has been studied intensively for its role in controlling …

NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …

The transcription factor nuclear factor (NF)-κB is activated in certain cancers and in response
to chemotherapy and radiation. The transcriptional activation of genes associated with cell …

The nuclear factor of κB (NF-κB) family of heterodimeric transcription factors plays an
instrumental role in immune, inflammatory, and stress responses. NF-κB induces the …

NF-κB is a pleiotropic transcription factor which controls the expression of many genes and
viruses. To date, there is good evidence, but no difinitive proof, for its role in tumor formation …

A role for the NF-κB family of transcription factors as tumor promoters is firmly established.
However, other data suggest that NF-κB can also inhibit tumor growth. Moreover, NF-κB …

NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

Several recent studies of mouse models of cancer have provided direct genetic evidence for
the critical role of NF-κB in carcinogenesis. While it has long been known that NF-κB is a key …

The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

NF-κB transcription factors have been suspected to be involved in cancer development
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …