The inflammatory nature of atherosclerosis is well established but the agent (s) that incite
inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible …

Particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of
interleukin 1β (IL-1β) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis …

Inflammation is a protective attempt by the host to remove injurious stimuli and initiate the
tissue healing process. The inflammatory response must be actively terminated, however …

Background Chronic inflammation of the arterial wall is a key element in the pathogenesis of
atherosclerosis, yet the factors that trigger and sustain the inflammation remain elusive …

Detection of microbial products by host inflammasomes is an important mechanism of innate
immune surveillance. Inflammasomes activate the caspase-1 (CASP1) protease, which …

An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of
situations of host 'danger', including infection and metabolic dysregulation,. Previous studies …

Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1–2% of the world's
population and is characterized by widespread joint inflammation. Interleukin-1 is an …

Background The NLR family, pyrin domain containing 3 (NLRP 3) inflammasome is an
interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in inflammatory …

Atherosclerosis underlies the leading cause of death in industrialized countries. 1
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs …

Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β
peptide drives cerebral neuroinflammation by activating microglia,. Indeed, amyloid-β …