Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

The heterogeneity of proteoglycans (PG) s contributes to their functional diversity. Many
functions depend on their ability to bind and modulate the activity of components of the …

Heparanase (HPSE-1) is involved in the degradation of both cell-surface and extracellular
matrix (ECM) heparan sulfate (HS) in normal and neoplastic tissues. Degradation of …

Perlecan is a major heparan sulfate proteoglycan (HSPG) of basement membranes (BMs)
and connective tissues. The core protein of perlecan is divided into five domains based on …

Perlecan is a major heparan sulfate proteoglycan of basement membranes and cell
surfaces. Because of its strategic location and ability to store and protect growth factors …

Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling
events controlling migration, proliferation, and differentiation. Its control of growth factor …

Perlecan, a modular proteoglycan carrying primary heparan sulfate (HS) side chains, is a
major component of blood vessel basement membranes. It sequesters growth factors such …

Introduction• Perlecan: a pro‐angiogenic proteoglycan• Endorepellin, a C‐terminal fragment
of perlecan with anti‐angiogenic activity• Syndecans in cancer biology• Glypicans and the …

Perlecan/HSPG2, a large heparan sulfate (HS) proteoglycan, normally is expressed in the
basement membrane (BM) underlying epithelial and endothelial cells. During prostate …

Abnormal expression of proteolygcans has been implicated in cancer and metastasis
primarily because these macromolecules are involved in the control of cell growth and …