Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …

Highlights•Extended antigen delivery immunization results in stronger humoral immune
responses.•Germinal centers are enhanced by extended antigen delivery.•Slow antigen …

Germline-targeting immunogens hold promise for initiating the induction of broadly
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …

Generating tier 2 HIV-neutralizing antibody (nAb) responses by immunization remains a
challenging problem, and the immunological barriers to induction of such responses with …

Immunodominance to nonneutralizing epitopes is a roadblock in designing vaccines against
several diseases of high interest. One hypothetical possibility is that limited CD4 T cell help …

A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs).
Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with …

Traditional vaccine development to prevent some of the worst current pandemic diseases
has been unsuccessful so far. Germline-targeting immunogens have potential to prime …

Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly
neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the …

The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …

How precursor frequencies and antigen affinities impact interclonal B cell competition is a
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …