Polycomb group (PcG) proteins are overexpressed in several human malignancies
including breast cancer. In particular, aberrant expression of BMI1 and EZH2 has been …

Abstract Background The polycomb group (PcG) protein BMI1 is an important regulator of
development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell …

ABSTRACT The Polycomb-group (PcG) gene BMI1 is required for the proliferation and self-
renewal of normal and leukemic stem cells. Overexpression of the BMI1 oncogene causes …

The polycomb group protein BMI1 has been shown to support normal stem cell proliferation
via its putative stem cell factor function, but it is not known if BMI1 may also act as a cancer …

Polycomb group proteins control the transcriptional memory of cells by maintaining the
stable silencing of specific sets of genes through chromatin modifications. Polycomb group …

Abstract Introduction PolycombGroup (PcG) proteins maintain gene repression through
histone modifications and have been implicated in stem cell regulation and cancer. EZH2 is …

Abstract The Polycomb group (PcG) transcription repressor BMI1 is highly expressed in
human cancers and is required for the clonogenic self-renewal and tumorigenesis of human …

The polycomb group protein BMI1 is an important regulator of cancer stem cell (CSC)
phenotype and is often overexpressed in cancer cells. Its overexpression leads to increase …

Polycomb group (PcG) genes are responsible for maintenance of cellular identity and
contribute to regulation of the cell cycle. Recent studies have identified several PcG genes …

Introduction: The polycomb group (PcG) proteins form chromatin-modifying complexes that
are commonly deregulated in cancer. The PcG protein BMI-I is overexpressed by various …