Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …

While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …

Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …

Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body
to establish secondary tumors. Although this is an inefficient process, the consequences are …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Metastasis is a complex clinical and biological problem presently under intense study, and
several model systems are in use to experimentally recapitulate and dissect the various …

Most cancer deaths are due to the systemic dissemination of cancer cells and the formation
of secondary tumors (metastasis) in distant organs. Recent years have brought impressive …

Unraveling the multifaceted cellular and physiological processes associated with metastasis
is best achieved by using in vivo models that recapitulate the requisite tumor cell-intrinsic …

Much has been written about the advantages and disadvantages of various oncology model
systems, with the overall finding that these models lack the predictive power required to …

Advances in cancer research have shown that a tumor can be likened to a foreign species
that disrupts delicately balanced ecological interactions, compromising the survival of …