Limitations, concerns and potential: attitudes of healthcare professionals toward preimplantation genetic testing using polygenic risk scores

M Siermann, O Valcke, JR Vermeesch… - European Journal of …, 2023 - nature.com
Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …

[HTML][HTML] A review of normative documents on preimplantation genetic testing: Recommendations for PGT-P

M Siermann, O Tšuiko, JR Vermeesch, T Raivio… - Genetics in …, 2022 - Elsevier
Purpose Recently, preimplantation genetic testing (PGT) for polygenic conditions (PGT-P)
has been introduced commercially. In view of the lack of specific guidance on this …

Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries

M Siermann, V van der Schoot, EM Bunnik… - Human …, 2024 - academic.oup.com
STUDY QUESTION Would the different regulatory approaches for preimplantation genetic
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …

A systematic review of the views of healthcare professionals on the scope of preimplantation genetic testing

M Siermann, Z Claesen, L Pasquier, T Raivio… - Journal of Community …, 2022 - Springer
Preimplantation genetic testing (PGT) involves testing embryos created through in vitro
fertilization for the presence of hereditary genetic disorders and chromosome abnormalities …

[HTML][HTML] The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …

The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users

S Zuckerman, S Gooldin, DA Zeevi… - Journal of Assisted …, 2020 - Springer
Purpose The decision to undergo preimplantation genetic testing (PGT) entails a variety of
personal and societal variables. Although PGT technology is widely accepted and used, few …

A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions

T Hughes, T Bracewell-Milnes, S Saso… - Human …, 2021 - academic.oup.com
BACKGROUND In pre-implantation genetic testing (PGT), fertile couples undergo IVF with
genetic testing of embryos to avoid conceptions with a genetic condition. There is an …

Decisional needs of patients considering preimplantation genetic testing: a systematic review

L Cheng, B Meiser, E Kirk, D Kennedy… - Reproductive …, 2022 - Elsevier
This systematic review reports on the needs and sources of support in patients' decision-
making regarding the uptake of preimplantation genetic testing (PGT). Five databases were …

Theory and practice of preimplantation genetic screening (PGS)

AG Schmutzler - European journal of medical genetics, 2019 - Elsevier
Objective In the context of artificial reproductive technology (ART) treatments with in vitro
fertilization (IVF) or intracytoplasmic sperm injection (ICSI), the purpose of genetic screening …

[HTML][HTML] Preimplantation genetic testing: preimplantation genetic testing for polygenic disease risk

NR Treff, D Marin, L Lello, S Hsu… - Reproduction, 2020 - rep.bioscientifica.com
Since its introduction to clinical practice, preimplantation genetic testing (PGT) has become
a standard of care for couples at risk of having children with monogenic disease, and for …