IL-11 is a unique growth factor derived from cells making up the HM. Although cloned based
on IL-6-like bioactivity, IL-11 and IL-6 have distinct biologic profiles (Table 1). IL-11, like …

Purified recombinant human interleukin-11 (rhuIL-11) was assessed for its in vivo effects on
the proliferation and differentiation of hematopoietic progenitors as well as its capacity to …

H'ematopoiesis, the production of blood cells, is a dy-~ namic process, the regulation of
which under normal conditions must be a tightly controlled process (1-7). Abnormalities in …

Interleukin 12 (IL-12) is a cytokine that supports the proliferation and activation of cytotoxic T
lymphocytes and natural killer (NK) cells. Recent evidence has suggested that IL-12 also …

Interleukin (IL)-3 is a multipotent hematopoietic growth factor produced by activated T cells,
monocytes/macrophages and stroma cells. The human IL-3 gene is located on chromosome …

The recently cloned interleukin 13 (IL-13) shares most investigated biological activities on B
lymphocytes and monocytes with IL-4. In this study we investigated for the first time the …

F weights of recombinant human (rh) and murine IL-11 are 19,144 daltons6 and 19,154
daltons, 2 respectively. Mature IRST ISOLATED IN 1990, interleukin-11 (IL-11) has proven to …

IL‐11, derived from a bone marrow stromal cell line, has pleiotropic effects on both
hematopoietic cells and nonhematopoietic cells. However, no previous studies have …

Interleukin 7 (IL-7) is a stromal cell-derived cytokine that stands out as being the only
cytokine identified to date on which development of B and T lymphocytes is absolutely …

Interleukin (IL)-12 synergizes with other cytokines to stimulate the proliferation and
differentiation of early hematopoietic progenitors in vitro. However, in vivo administration of …