FTY720, given iv or orally at 0.03 mg/kg or more, significantly prolonged skin allograft
survival in a dose-dependent manner and showed more potent immunosuppressive activity …

FTY720, a novel immunosuppressant, sequesters circulating mature lymphocytes,
especially T cells, within lymph nodes and Peyer's patches by accelerating lymphocyte …

FTY720, a novel immunosuppressant, prolonged the survival of WKAH skin allografts
transplanted into MHC-incompatible F344 rats. In this allograft model, the median survival …

One major role of the thymus is to provide the peripheral immune system with mature T cells,
but the mechanisms involving the cellular export are not fully understood. In this study, we …

FTY720, a new and potent immunosuppressant, causes in animal models a rapid, reversible
reduction of all subsets of peripheral blood lymphocytes, inducing their migration to …

Abstract FTY720 (2-amino-2-(2-[4-octylphenyl] ethyl)-1, 3-propanediol hydrochloride)
prolongs survival of solid organ allografts in animal models. Mechanisms of FTY720 …

7 (6–7) 7 (6–7) 7 (6–7) 0.1 11 (9–12) ND ND 0.3 16 (14–19) ND 7 (7–9) 1 20 (18–21) ND 9
(8–10) 3 23 (20–25) 8 (8–9) 11 (10–12) 10 ND 11 (10–12) 22 (20–23) 30 ND 21 (19–22) ND …

Abstract FTY720 (2‐amino‐2‐[2‐(4‐octylphenyl) ethyl] propane‐1, 3‐diol hydrochloride) is
an orally available immunomodulatory agent that induces severe peripheral blood …

Current standard drugs used to prevent organ graft rejection all interfere with discrete sites
in the T-cell/B-cell activation cascade. They can be classified as inhibitors of cytokine …

The immunomodulator FTY720 (FTY) has been shown to be beneficial in experimental
models of organ transplantation and autoimmunity. We show that FTY significantly inhibited …