Understanding of the genetic regulation of puberty timing has come largely from studies of
rare disorders and population-based studies in women. Here, we report the largest genomic …

Studies of pubertal timing in the general population have provided new knowledge about
the genetic architecture of this complex trait. Increasing attention paid to sex-specific effects …

The timing of puberty is highly variable and is associated with long-term health outcomes. To
date, understanding of the genetic control of puberty timing is based largely on studies in …

Understanding the regulation of puberty timing has relevance to developmental and human
biology and to the pathogenesis of various diseases. Recent large-scale genome-wide …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and
cardiovascular disease in women and therefore represents a potential target for early …

Little is known about genes regulating male puberty. Further, while many identified pubertal
timing variants associate with age at menarche, a late manifestation of puberty, and body …

Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …

OBJECTIVE Early pubertal onset in females is associated with increased risk for adult
obesity and cardiovascular disease, but whether this relationship is independent of …

Obesity is of global health concern. There are well-described inverse relationships between
female pubertal timing and obesity. Recent genome-wide association studies of age at …