In multicellular organisms, cell types must be produced and maintained in appropriate
proportions. One way this is achieved is through committed progenitor cells or extrinsic …

A full understanding of the developmental process requires fine-scale characterization of
cell divisions and cell types, which are naturally organized as the developmental cell …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single cell zygote gives rise to millions of cells …

Natural and induced somatic mutations that accumulate in the genome during development
record the phylogenetic relationships of cells; whether these lineage barcodes capture the …

Correct and timely lineage decisions are critical for normal embryonic development and
homeostasis of adult tissues. Therefore, the search for fundamental principles that underlie …

Fueled by recent advances in single cell biology, we are moving away from qualitative and
undersampled assessments of cell identity, toward building quantitative, high-resolution cell …

Quantifying the number of progenitor cells that found an organ, tissue or cell population is of
fundamental importance for understanding the development and homeostasis of a …

The origin and evolution of cell types has emerged as a key topic in evolutionary biology.
Driven by rapidly accumulating single-cell datasets, recent attempts to infer cell type …

Commitment to specific cell lineages is critical for mammalian embryonic development.
Lineage determination, differentiation, maintenance, and organogenesis result in diverse life …

Single cell biology is currently revolutionizing developmental and evolutionary biology,
revealing new cell types and states in an impressive range of biological systems. With the …