[HTML][HTML] Environmental chemicals, breast cancer progression and drug resistance

M Koual, C Tomkiewicz, G Cano-Sancho… - Environmental …, 2020 - Springer
Breast cancer (BC) is one of the most common causes of cancer in the world and the second
leading cause of cancer deaths among women. Mortality is associated mainly with the …

Tumor microenvironment promotes breast cancer chemoresistance

U Mehraj, AH Dar, NA Wani, MA Mir - Cancer chemotherapy and …, 2021 - Springer
Breast cancer is presently the most predominant tumor type and the second leading cause
of tumor-related deaths among women. Although advancements in diagnosis and …

[HTML][HTML] Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms

KM Rodgers, JO Udesky, RA Rudel, JG Brody - Environmental research, 2018 - Elsevier
Background Many common environmental chemicals are mammary gland carcinogens in
animal studies, activate relevant hormonal pathways, or enhance mammary gland …

Tumor microenvironment-mediated chemoresistance in breast cancer

N Samadi, B Barazvan, JS Rad - The Breast, 2016 - Elsevier
Therapy resistance or tumor relapse in cancer is common. Tumors develop resistance to
chemotherapeutic through a variety of mechanisms, with tumor microenvironment (TM) …

[HTML][HTML] High AHR expression in breast tumors correlates with expression of genes from several signaling pathways namely inflammation and endogenous …

S Vacher, P Castagnet, W Chemlali, F Lallemand… - PloS one, 2018 - journals.plos.org
Increasing epidemiological and animal experimental data provide substantial support for the
role of aryl hydrocarbon receptor (AhR) in mammary tumorigenesis. The effects of AhR have …

[HTML][HTML] Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

HY Xie, ZM Shao, DQ Li - Chinese journal of cancer, 2017 - Springer
Distant metastasis to specific target organs is responsible for over 90% of breast cancer-
related deaths, but the underlying molecular mechanism is unclear. Mounting evidence …

[HTML][HTML] A review of the role of emerging environmental contaminants in the development of breast cancer in women

S Siddique, C Kubwabo, SA Harris - Emerging Contaminants, 2016 - Elsevier
The incidence of breast cancer is on a rise worldwide; it is a disease having a complex
etiology. Besides genetics, environmental and other lifestyle factors play a role in the …

Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative …

SJ Sauer, M Tarpley, I Shah, AV Save… - …, 2017 - academic.oup.com
Emerging evidence from epidemiological studies suggests a link between environmental
chemical exposure and progression of aggressive breast cancer subtypes. Of all clinically …

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation

JM Hall, MA Barhoover, D Kazmin… - Molecular …, 2010 - academic.oup.com
The current statistics associated with breast cancer continue to show a relatively high
recurrence rate together with a poor survival for aggressive metastatic disease. These …

[HTML][HTML] The breast tumor microenvironment: A key player in metastatic spread

LEL Terceiro, CA Edechi, NM Ikeogu, BE Nickel… - Cancers, 2021 - mdpi.com
Simple Summary The spread of breast cancer to distant parts of the body (metastasis) is the
major cause of death in breast cancer patients. Research has shown that apart from the …