The use of quorum-sensing inhibitors (QSI) has been proposed as an alternative strategy to
combat antibiotic resistance. QSI reduce the virulence of a pathogen without killing it and it is …

Objectives Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro
are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and …

Bacterial resistance to conventional antibiotics combined with an increasing
acknowledgement of the role of biofilms in chronic infections has led to a growing interest in …

Although the exact role of quorum sensing (QS) in various stages of biofilm formation,
maturation, and dispersal and in biofilm resistance is not entirely clear, the use of QS …

Abstract Decades after the Golden Age of antibiotics, it is evident that antibiotic resistance is
rapidly evolving and spreading among clinically relevant pathogens. The medical need for …

Pseudomonas aeruginosa is a ubiquitous pathogen that is the leading cause of chronic
infections. Bacterial biofilm formation facilitates CF development and restricts the anti …

As single-and mixed-species biofilms, Staphylococcus aureus and Pseudomonas
aeruginosa cause difficult-to-eradicate chronic infections. In P. aeruginosa, pseudomonas …

Pseudomonas aeruginosa plays an important role in chronic lung infections among patients
with cystic fibrosis (CF) through its ability to form antibiotic-resistant biofilms. In P …

Antimicrobial therapy against extensively drug-resistant (XDR) P. aeruginosa biofilms is less
efficient compared to the treatment of equal bacterial counts of free-floating planktonic cells …

Pseudomonas aeruginosa biofilms contribute to its survival on biotic and abiotic surfaces
and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the …